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Each user can choose which language they want to work with, no matter what is the account's default language. You can switch from English to French at anytime, by clicking the corresponding link at the upper right of the interface. Each user can also select the default language of their email notifications...
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Yes. Each user can define his/her time zone under "My Office -> My Preferences". Thus, the user's parameters, for date and time formats, will be set in accordance with his/her time zone. This does not affect the company's account settings.